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  • How-to guides

    Selank: Cognitive / Neuro research guide

    In short: Selank is a synthetic tuftsin-derived heptapeptide anxiolytic that allosterically modulates GABAA receptors and upregulates hippocampal BDNF expression. It is studied in preclinical (cell and animal) research and is supplied strictly for laboratory use, not for human or clinical use.

    Not medical advice. Selank is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.

    Selank at a glance

    Compound type
    Research peptide
    Research category
    Cognitive / Neuro
    Also known as
    Selank, TP-7, Selanc, TKPRPGP, Tuftsin Analogue, Thr-Lys-Pro-Arg-Pro-Gly-Pro, Selank Acetate, PL14736
    Molecular weight
    751.87 Da
    Research-grade purity
    >99% HPLC
    Evidence context
    Preclinical / research use only
    Regulatory status
    Not an approved medicine. Supplied as a research compound
    Last reviewed
    16 June 2026

    What to know first

  • Allosterically modulates GABAA receptor affinity, anxiolytic profile comparable to benzodiazepines without sedation or dependence
  • Rapidly elevates BDNF expression in hippocampal neurons for neurotrophic support
  • Modulates monoamine neurotransmitter levels, significantly alters noradrenaline, dopamine, and serotonin concentrations
  • Inhibits enkephalin-degrading enzymes to potentiate endogenous opioid peptide signaling
  • Details and limits sit in the sections below. Research use only.

    What Selank is

    Selank is a Russian anxiolytic heptapeptide derived from the immune peptide tuftsin that produces benzodiazepine-like calming effects through GABAA modulation - without sedation, amnesia, or dependence.

    One-paragraph overview from our research datasheet. Still scientific, but faster to read than the full mechanism list below.

    Selank is a synthetic tuftsin-derived heptapeptide anxiolytic that allosterically modulates GABAA receptors and upregulates hippocampal BDNF expression.

    Research contexts

    Peer-reviewed papers discuss Selank in specific lab settings. The points below reflect research questions, not health claims.

    Research vs. personal use: Literature describes experiments in cells and animals. That is distinct from real-world use. Our products are for laboratory research only.

    Typical study contexts

  • Stress, sleep and neuronal signalling in rodents.
  • Some compounds appear in small exploratory human studies elsewhere. Still not DIY use.
  • Allosterically modulates GABAA receptor affinity, anxiolytic profile comparable to benzodiazepines without sedation or dependence.
  • Rapidly elevates BDNF expression in hippocampal neurons for neurotrophic support.
  • Modulates monoamine neurotransmitter levels, significantly alters noradrenaline, dopamine, and serotonin concentrations.
  • Inhibits enkephalin-degrading enzymes to potentiate endogenous opioid peptide signaling.
  • Why Cognitive / Neuro research matters

    Cognitive-related peptides are explored for stress pathways and neuronal signalling in animals. Not treatments for human brain conditions.

    Mechanisms (technical review)

    Our datasheet lists mechanistic themes from preclinical work. These are research endpoints, not health claims.

  • Allosterically modulates GABAA receptor affinity, anxiolytic profile comparable to benzodiazepines without sedation or dependence
  • Rapidly elevates BDNF expression in hippocampal neurons for neurotrophic support
  • Modulates monoamine neurotransmitter levels, significantly alters noradrenaline, dopamine, and serotonin concentrations
  • Inhibits enkephalin-degrading enzymes to potentiate endogenous opioid peptide signaling
  • Regulates IL-6 expression and T-helper cell cytokine balance for immunomodulatory effects
  • Demonstrated antiasthenic and psychostimulant effects beyond pure anxiolysis in clinical trials
  • Lab handling & preparation

  • Storage: Lyophilised powder: store in freezer (−20 °C). Reconstituted: refrigerate 1–6 °C, away from sunlight. Use within the validated stability window for the specific batch and formulation.. See the storage guide.
  • Research dosing context: Literature typically discusses 250–500 μg intranasal; 150–300 μg subcutaneous. Once daily intranasal (0.15% solution, 2–3 drops per nostril) Complete plasma clearance within 10 minutes post-administration. C-terminal Pro-Gly-Pro extension substantially extends biological activity duration versus native tuftsin (t½ seconds). Intranasal route preferred for non-invasive CNS delivery. Metabolized rapidly in the liver and eliminated via renal excretion. Russian clinical doses: 150–300 μg intranasally, with anxiolytic effects observed within 10–15 minutes of administration.
  • Preparation: Follow the reconstitution guide. Confirm volumes with the calculator.
  • Purity check: Use the COA reading guide and the published Selank Certificate of Analysis.
  • Common Questions People Are Asking

    What is Selank and how does it work?

    Selank is a synthetic seven-amino-acid (heptapeptide) derivative of the immune peptide tuftsin, with a Pro-Gly-Pro tail for stability, studied as an anxiolytic and nootropic research compound. The leading mechanistic hypothesis is allosteric modulation of the GABAergic system - it changes the expression of GABA-related genes rather than binding the GABA-A receptor as a direct agonist - alongside effects on monoamine neurotransmitters. New-U supplies it for laboratory research only.

    What does the Selank research actually show?

    The headline finding is a Russian clinical study where Selank produced anxiolytic effects similar to the benzodiazepine medazepam, plus additional antiasthenic (anti-fatigue) and psychostimulant activity (Zozulya et al., 2008). Mechanistic work shows it modulates GABAergic gene expression (Volkova et al., 2016). These are research findings - mostly from Russian clinical and animal studies - and are not a promise of any effect in humans.

    How does Selank compare with benzodiazepines?

    A Russian clinical study compared Selank directly with medazepam and found comparable anxiolytic effect. The reported difference is in the side-effect profile: review and clinical literature describe Selank as not producing sedation, amnesia, tolerance, dependence or withdrawal, which are common with benzodiazepines. It is studied as an allosteric GABAergic modulator rather than a direct GABA-A agonist.

    How long does Selank take to work, and what is its half-life?

    Plasma clearance is rapid - effectively complete within minutes of administration - but the Pro-Gly-Pro tail extends functional activity far beyond the parent tuftsin, whose half-life is measured in seconds. Russian clinical and review sources describe a fast onset for the anxiolytic effect via the intranasal route. We report these figures descriptively from the literature and make no dosing recommendation.

    Is Selank legal, and is it FDA-approved?

    Selank is not FDA-approved in the United States and is sold strictly as a research chemical for laboratory use, not for human consumption. It is a registered/approved anxiolytic medicine in Russia. Legal status varies by jurisdiction, so confirm your local rules before purchasing.

    How does Selank compare with Semax?

    Both are Russian heptapeptides with Pro-Gly-Pro stabilising tails and intranasal delivery, and they share several effects such as monoamine modulation. Selank emphasises anxiolysis and stress buffering; Semax (an ACTH(4-10) analogue) emphasises cognition and neuroprotection. They are sometimes studied together in protocols covering both the calm and the focus dimensions.

    How should Selank be stored?

    Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The Pro-Gly-Pro tail gives Selank much better stability than parent tuftsin (which has a half-life measured in seconds), but standard peptide handling still applies - avoid repeated freeze-thaw cycles.

    Is this page medical advice? Can I use Selank for my health?

    No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.

    Where do I find Selank specs, purity certificates and pricing?

    Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.

    Related peptide guides

    Other compounds researchers often read about alongside Selank.

  • Semax - companion guide
  • Cerebrolysin - companion guide
  • DSIP - companion guide
  • Adamax - companion guide
  • Scientific sources & further reading

    Primary literature and registries for Selank, plus mainstream coverage of the peptide category. Research use only - not medical advice.

    Databases & literature:

  • PubMed: peer-reviewed literature on Selank
  • ClinicalTrials.gov: registered studies on Selank
  • Selank: Wikipedia
  • Peptides in the news:

  • WebMD: consumer health reference
  • BBC News: Health
  • CNN Health: “Peptides: what to know about the wellness trend”
  • Sky News: “Can peptides make America healthy again?”
  • Sky News: “Inside the exploding US peptides craze” (video)
  • Sky News Australia: “Black market peptide trade explodes as influencers fuel uptick in use”
  • Sky News Australia: “Backyard peptide boom sparks alarm” (video)
  • Sky News Australia: “Oprah reveals struggle with shame of weight-loss drugs”
  • Ready to order? View full product specs

    Access concentration, batch info, variants, and current pricing on our shop.

    Also known as: Selank, TP-7, Selanc, TKPRPGP, Tuftsin Analogue, Thr-Lys-Pro-Arg-Pro-Gly-Pro, Selank Acetate, PL14736

    PRECISION. PURITY. PERFORMANCE.

    Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.

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    © 2026 New-U Research Compounds · new-u.io — Copyright held with Hilxera Distribution Services LLC. All rights reserved.