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Hexarelin: HGH / Somatropin research guide
In short: Hexarelin (Examorelin), potent hexapeptide GHS-R1a agonist producing synergistic GH release with GHRH and cardioprotective CD36 receptor activation. It is studied in preclinical (cell and animal) research and is supplied strictly for laboratory use, not for human or clinical use.
Not medical advice. Hexarelin is a research compound. This guide does not provide dosing, diagnosis, therapy recommendations, or claims about effects in humans.
Hexarelin at a glance
What to know first
Details and limits sit in the sections below. Research use only.
What Hexarelin is
Hexarelin is a potent six-amino-acid growth hormone secretagogue that uniquely activates both the ghrelin receptor (for GH release) and CD36 scavenger receptors on cardiomyocytes (for cardioprotective signalling).
One-paragraph overview from our research datasheet. Still scientific, but faster to read than the full mechanism list below.
Hexarelin (Examorelin), potent hexapeptide GHS-R1a agonist producing synergistic GH release with GHRH and cardioprotective CD36 receptor activation.
Research contexts
Peer-reviewed papers discuss Hexarelin in specific lab settings. The points below reflect research questions, not health claims.
Research vs. personal use: Literature describes experiments in cells and animals. That is distinct from real-world use. Our products are for laboratory research only.
Typical study contexts
Why HGH / Somatropin research matters
Growth-hormone axis peptides are studied for GH/IGF signalling in animals and cells. Focus stays on endocrine biology, not prescribing.
Mechanisms (technical review)
Our datasheet lists mechanistic themes from preclinical work. These are research endpoints, not health claims.
Lab handling & preparation
Common Questions People Are Asking
How is hexarelin different from GHRP-6?
Hexarelin is a more potent version of the GHRP-6 scaffold with two non-natural amino-acid substitutions (D-2-methyltryptophan and D-phenylalanine) that improve stability and GH-releasing potency. It also has clearer CD36-mediated cardiac effects than the simpler GHRP-6.
What is the CD36 mechanism doing in cardiac tissue?
CD36 is a scavenger receptor that handles fatty acid uptake and calcium channel modulation in cardiomyocytes. Hexarelin activation of cardiac CD36 improves calcium handling and has been proposed as a mechanism for its cardioprotective effects in post-ischemic injury models.
Does hexarelin cause cortisol elevation?
Yes, hexarelin produces some cortisol and prolactin elevation at higher doses, more than ipamorelin but generally less than GHRP-6. Low-dose protocols minimise those secondary effects while preserving GH release.
How should hexarelin be stored?
Keep the lyophilised powder frozen at −20 °C. After reconstitution with bacteriostatic water, refrigerate at 1-6 °C and protect from light. The non-natural amino acid substitutions give it better shelf stability than simpler GHRPs.
Hexarelin vs ipamorelin - how do they compare?
Both are ghrelin-receptor (GHSR) agonists that release growth hormone, but hexarelin is the more potent GH releaser and adds CD36-mediated cardiac activity, while ipamorelin is the cleaner, more selective option with minimal cortisol, prolactin or appetite effect. Hexarelin also desensitises faster with continuous exposure. See our Hexarelin vs Ipamorelin research comparison for the full mechanism breakdown.
Hexarelin vs GHRP-2 - what is the difference?
Both are hexapeptide ghrelin-receptor agonists, but hexarelin is the more potent GH releaser per dose and uniquely adds CD36-mediated cardiac activity, while GHRP-2 produces a more modest GH pulse with a milder cortisol and prolactin profile. Hexarelin also desensitises (loses effect) faster with sustained exposure, which is why research protocols built around it favour lower amounts and cycling. Both are supplied strictly for laboratory research, not human use.
What hexarelin dosage is used in research?
Research protocols describe low-microgram subcutaneous amounts, often split through the day, with lower amounts used to limit cortisol/prolactin rise and receptor desensitisation. New-U publishes this as descriptive research context only - it is not a dosing instruction, and hexarelin is supplied strictly for laboratory research, not human use.
What is hexarelin studied for?
Beyond growth-hormone release, hexarelin is studied for CD36-mediated cardioprotective effects in post-ischaemic injury models and for calcium-handling in cardiomyocytes - an angle the simpler GHRPs lack. These are preclinical research findings; New-U makes no therapeutic claims and sells hexarelin for research use only.
Does hexarelin lose effect over time (desensitisation)?
Yes - continuous high-amount exposure downregulates the ghrelin receptor and blunts the GH response faster than with ipamorelin, which is why research protocols favour lower amounts and cycling. Reported for research context only, not a human-use protocol.
Is this page medical advice? Can I use Hexarelin for my health?
No, and no. This article is educational only. We do not provide dosing, medical recommendations, or health claims. Our products are sold strictly for laboratory research, not for personal use of any kind.
Where do I find Hexarelin specs, purity certificates and pricing?
Open the shop listing via “View product details.” There you will see batch specs, the Certificate of Analysis (COA), concentration, purity grade, and available SKUs with current pricing.
Related peptide guides
Other compounds researchers often read about alongside Hexarelin.
Scientific sources & further reading
Primary literature and registries for Hexarelin, plus mainstream coverage of the peptide category. Research use only - not medical advice.
Databases & literature:
Peptides in the news:
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Also known as: Examorelin, EP-23905, MF-6003, Hexarelin Acetate, His-D-2-Me-Trp-Ala-Trp-D-Phe-Lys-NH2
PRECISION. PURITY. PERFORMANCE.
Research peptides at >99% HPLC-verified purity, third-party tested by Janoshik Analytical & Freedom Diagnostics, with Certificates of Analysis published per released batch. Supplied strictly for laboratory research use.
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